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To browse Academia. Purpose: To follow the clinical course of children and adolecents with absence syndromes, estimate the percentage of patients entering remis- sionwithmonotherapyorcombinationofantiepilepticdrugs AEDs and identifyprognosticfactorsofearlyremission. Method: The study population consisted of 65 children, 34 girls and 31 boys, 3β14 years old mean 6.
Allchildren received treatment with one or more AEDs. Results: Patients included in the study were followed up for a mean of 2. Among the group of children with CAE, Childhood absence epilepsy CAE is a common pediatric epilepsy syndrome with distinct seizure semiology, electroencephalography EEG features, and treatment. A diagnosis of CAE can be obtained during an office visit with a careful history, physical exam including prolonged hyperventilation, and a routine EEG.
The treatment of choice for CAE with absence seizures only is ethosuximide. Valproic acid and lamotrigine are also effective treatments for many patients, but when compared to ethosuximide, valproic acid has more adverse effects and lamotrigine is less effective.
Attention to predictors of response to treatment, including clinical, electrographic, and genetic factors, is increasing. Refractory CAE occurs in fewer than half of patients, and treatment strategies are available, though efficacy data are lacking. Careful assessment and treatment of psychosocial comorbidities is essential in caring for patients with CAE.
Key Points Ethosuximide, valproate, and lamotrigine each have a role as treatments for childhood absence epilepsy. Care of children with childhood absence epilepsy should go beyond drug treatment and address associated behavioral and psychosocial conditions as well. Epileptic disorders : international epilepsy journal with videotape, Childhood absence epilepsy CAE typically starts between four and seven years of age.