Official websites use. Share sensitive information only on official, secure websites. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control.
These low levels showed heterogeneity among HIC. These findings allow the identification of HIC with a low risk of progression who may not need treatment.
All patients gave a written informed consent. We then categorized this slope into two categories of HIC, those who had a decrease in slope over time, which was the group of interest, and those who had an increase or a stable slope over time, which was the referent group.
We tested each factor or marker significantly associated with these outcomes in two separate univariate models. All these analyses gave similar results to those obtained with the threshold value. The patient characteristics at inclusion are reported in Table 1 ; Data concerning activation and inflammation were available for a subgroup of HIC.
This marker is not perfect as it includes both integrated and unintegrated forms and could overestimate the reservoir size. However, the role of the defective forms is associated with viral proteins production, resulting in immune activation, which participates to the pathogenesis and maintenance of HIV reservoirs 12 , 15 , Moreover, this assay has a greater precision and reproducibility in the context of a low level of detection than is possible for other markers of HIV reservoirs 12 , 15 , In this large cohort of HIC, we confirmed that HIV blood reservoirs are low; in fact, the reservoirs in HIC are much lower than those in adults and children who have received combined antiretroviral treatment for several years 1 , 12 , Graf et al.
