Christian Stigloher is a molecular cell biologist and electron microscopist. The main focus of his research have been neurons, from early development as progenitor cells to the final differentiated state with functional synapses. Christian is particularly interested in understanding the dynamic behavior and architecture of cells and to combine this information with the molecular factors at play.
He used zebrafish as model to unravel molecular components of an early patterning process in the nervous system that separates the eye field from the telencephalic progenitor pool.
Vertebrate brains crucially rely on neural progenitor pools as source of undifferentiated and proliferating cells during development and partly also throughout life-time. He then focused on the molecular processes regulating the neural progenitor pool at the midbrain-hindbrain boundary MHB where he participated in a project that discovered a novel microRNA mediated process that regulates the MHB progenitor pool.
As postdoc he then went on to use the small nematode C. As postdoctoral-fellow he learned to apply advanced electron microscopy techniques such as high pressure freezing and established electron tomography as tool to study synaptic architecture at the nanoscale in 3D. A special interest of his research is to combine microscopy techniques in a so called correlated light and electron microscopy CLEM approach.
Thereby one can profit from the advantages of both techniques, allowing access to ultrastructural information with the knowledge of the localization of molecular factors. Animation stoppen. Christian Stigloher Group Leader. Am Hubland. Raum: DK E-Mail: christian. Link, F. Erbacher, C. Holzapfel, R. Britz, S. Fazeli, G. Andreska, T. Lichter, K.
