Official websites use. Share sensitive information only on official, secure websites. Corresponding author. Phone: 33 4 73 75 48 Fax: 33 4 73 75 48 E-mail: chenquell chu-clermontferrand. Her sexual partner was secondarily diagnosed with HIV infection, and transmission was confirmed by phylogenetic analysis.
The unequal performance of many of the serologic and molecular assays commercially available leads to delays in diagnosis and affects patient management. A year-old Caucasian woman was admitted on 9 February to the internal medicine ward of the hospital of a medium-size city in central France for a hyperalgesic syndrome and a fever of Severe myalgia of the lower limbs required analgesic treatment and was associated with nonpainful jugular and axillary lymphadenopathy.
She had not traveled abroad in the previous few months. The first biological investigation showed the presence of activated lymphocytes and biochemical signs of hepatic cytolysis alanine aminotransferase level, 6 times normal; aspartate aminotransferase level, 3. Serological investigations for bacterial infections syphilis, yersinia, Q fever, and mycoplasma were negative.
Tests for serological markers of viral hepatitis A hepatitis A virus immunoglobulin M [IgM] , B hepatitis B surface antigen and antibody to hepatitis B core antigen , and C antibody to hepatitis C virus were negative. Serological assays for cytomegalovirus, Epstein-Barr virus, and toxoplasmosis revealed the presence of IgG but not IgM antibodies, which is suggestive of past infections.
A screening test for human immunodeficiency virus type 1 HIV-1 or HIV-2 infection was performed 1 week later 15 February , when the patient reported having had sexual relations with an occasional partner at the beginning of January.
