Our objective was to understand the functional link between the composition of faecal microbiota and the clinical characteristics of adults with short bowel syndrome SBS. Each patient exhibited a diverse lactic acid bacteria composition L. Two patients, belonging to the LA group and who particularly accumulated faecal D-lactate, were at risk of D-encephalopathic reactions. Furthermore, all patients of the NLA group and those accumulating preferentially L isoform in the LA group had never developed D-acidosis.
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Micro-organisms colonizing the digestive tract microbiota play a key role in nutrition and health. In general, adult human microbiota is mainly composed of a phylogenic core containing Firmicutes , Bacteroidetes , and Actinobacteria [1] , [2]. It is well known that the composition and mostly, molecular functions of microbiota are altered by age, nutrition, environment and pathologic status [3] , [4] , [5] , [6].
The protective or harmful role of bowel microbiota depends on the pathology, and thus microbiota specifically influences the aetiopathogenesis of each human disease. In patients with type II short bowel syndrome SBS , the aetiopathogenesis has been associated with an extreme dysbiosis [7] , [8] , [9] , [10].
These patients have had a massive small bowel resection, leaving less than cm joining with a partial or an entire colon [11].
