Official websites use. Share sensitive information only on official, secure websites. All correspondence should be addressed to Alan S. Brown, M. Autoimmune disruption may contribute to risk for autism; however, since previous studies relied upon clinical diagnoses, exposure misclassification and recall bias are limitations.
Thyroid peroxidase antibody TPO-Ab is an autoantibody involved in autoimmune thyroiditis. The study was based on a nested case-control design of the Finnish Prenatal Study of Autism FiPS-A , a national birth cohort that includes prospectively drawn archived maternal serum specimens from virtually the entire pregnant population of Finland. Cases of childhood autism ICD F Data were analyzed by conditional logistic regression for matched sets. Measures of maternal thyroid hormones did not differ between groups.
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These findings provide the first biomarker-based evidence that a class of known maternal autoimmune disorders is related to autism in offspring. Autism is a complex neurodevelopmental disorder characterized by impaired language, disrupted reciprocal social interactions, and stereotyped behaviors and interests 1. Genetic factors are known to play a major role in autism though its etiology is still largely unknown 2. Recent evidence has also implicated an emerging role for environmental factors 3 β Moreover, some autoimmune disorders may be more frequent in mothers and other relatives of autism probands.
Early studies, based on questionnaires of family members, reported that the prevalence of any autoimmune disorder, and one or more of a number of specific autoimmune disorders was significantly higher in families of autism probands than comparison subjects 16 , In another study, autoimmune thyroiditis in only the maternal lineage was significantly related to regressive autism Other specific autoimmune diagnoses associated with ASD included parental rheumatoid arthritis 16 and rheumatic fever first degree relatives These studies were limited, however, by use of diagnoses from family member self-reports and lack of validation of responses predisposing to diagnostic misclassification, by recall bias, and by low response rates to questionnaires, increasing the likelihood of selection bias.
More recent studies utilizing health plan databases and registries have demonstrated associations between ASD and maternal psoriasis, type I diabetes 19 β 21 , ulcerative colitis, and celiac disease Overall, maternal autoimmune disorders were more commonly associated with autism than paternal autoimmune disorders, suggesting effects during pregnancy on autism risk, though the type of autoimmune disorders related to autism varied between studies.
