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In hospitalized patients with skin and soft tissue infections SSTIs , intravenous IV empiric antibiotic treatment is initiated. The best time point for switching from IV to oral treatment is unknown.
In a nonrandomized trial, we prospectively enrolled patients hospitalized with SSTI from July to May at 3 institutions. Clinical and biochemical response data during the first week and at follow-up after 30 days were analyzed. Patients fulfilling criteria for the switch from IV to oral antibiotics were assigned to the intervention group.
The primary outcome was a composite definition consisting of the proportion of patients with clinical failure or death of any cause. Ninety-seven There were 5 5. Keywords: cellulitis, erysipelas, oral antibiotics, skin and soft tissue infection.
Skin and soft tissue infections SSTIs ie, erysipelas and cellulitis without abscess formation or necrosis rank among the most common community-acquired bacterial infections. The empiric treatment recommendations for SSTIs in our institutions include amoxicillin-clavulanate as the first choice. In the case of penicillin allergy, oral clindamycin is a possible alternative. Depending on the severity of the disease, a decision for hospitalization or outpatient treatment is made. In hospitalized patients, intravenous IV empiric antibiotic treatment is commonly initiated.
