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Analysis of a retrospectively documented cohort of consecutive COVID cases recorded between March 7, and May 24, as part of an infection control investigation program, with prospective follow-up interviews gathering information on type and duration of symptoms and COVID risk factors until June 26, Of total cases, The incidence during the time period was The case fatality ratio CFR was 2.
Among fatal cases, the mean age was The median duration of general illness was 10 days. During follow-up, 8. We report data on type and duration of symptoms, and clinical severity of nearly all A broad range of symptoms and symptom duration was seen, some of them lasting several weeks in a considerable number of cases. The case-fatality ratio was 2. Asymptomatic cases may be underrepresented due to the nature of the study. The online version of this article Known risk factors for severe disease are higher age, hypertension, cardiovascular and chronic pulmonary disease, diabetes, immunodeficiency, smoking, male gender [ 5 ].
Children might be less often affected than adults [ 6 ]. The most frequent symptoms are fever, cough and rhinitis [ 4 ]. Data on symptom duration and long-term alterations are incomplete yet. We focus on clinical and epidemiologic data, including frequency and duration of symptoms, risk factors for COVID, and characteristics of fatal cases. Information was collected via personal interviews during infection control investigations and follow-up interviews from the first reported case in March until the end of the wave in May To study the characteristics and chronology of cases in Regensburg, we analyzed a retrospectively documented cohort of consecutive COVID cases by date of reporting in the city and county of Regensburg, Bavaria from the first reported case on March 7, through May 24, The total number of cases in the respective period was ; 5 cases were not included due to a delay in reporting.
We applied the case definition according to criteria put forth by the Robert Koch Institute RKI , the federal government agency responsible for disease control and prevention [ 7 ]. Only new cases were registered. Suspected cases, individuals with a negative PCR result, and those with serological detection of antibodies only or typical morphological alterations in computed tomography only were not considered cases.
