Official websites use. Share sensitive information only on official, secure websites. Brouwer 1 ; D. Ellis 2 ; A. Antanasijevic 3 ; A. Yasmeen 4 ; Z. Berndsen 3 ; T. Bijl 1 ; J. Burger 1 ; B. Nickerson 2 ; C. Cottrell 3 ; J. Allen 5 ; I. Bontjer 1 ; M. Crispin 5 ; D. Baker 2 ; A. Ward 3 ; J. Moore 4 ; P. Klasse 4 ; N. King 2 and R. Sanders 1. The protruding SOSIP trimers maintain their antigenic integrity as observed by surface plasmon resonance and, in contrast to their soluble counterparts, induce strong activation of cognate B cells in vitro.
This may provide a considerable advantage over particles that are assembled intracellularly i. Madani 1 ; A. Princiotto 2 ; L. Mach 3 ; J. Richard 4 ; B. Hora 5 ; C. Zhao 6 ; T. Bradley 7 ; B. Melillo 8 ; A. Finzi 9 ; B. Haynes 10 ; A. Smith 8 ; S.
Santra 11 ; J. Moss 12 ; M. Baum 12 and J. Sodroski 2. Three groups of monkeys were used in the present study. The protective immune response persists for at least six months after vaccination. Jones 1 ; R.
Wyatt 3 ; C. LaBranche 4 ; X. Shen 5 ; G. Tomaras 5 ; D. Montefiori 5 ; B. Moss 3 ; J. Clements 6 ; D. Barouch 7 ; P. Kozlowski 8 ; R. Varadarajan 2 and R. Amara 1. Here we evaluate the immunogenicity and efficacy of oral vaccination and compare it with systemic vaccinations in rhesus macaques RM.
All animals were challenged intrarectally at around five months after the final immunization with a pathogenic SHIVP3 for a maximum of six challenges. They also show that MVA prime followed by a gp trimer boost can provide a significant protection against intrarectal SHIV challenges. Tomaka 1 ; D. Stieh 2 ; D. Barouch 3 ; M. Robb 4,5 ; N. Michael 4 ; G.
