Official websites use. Share sensitive information only on official, secure websites. Fusobacterium nucleatum activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis. We characterized F nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer CRC specific survival.
We conducted deep sequencing of nusA , nusG , and bacterial 16s rRNA genes in tumors from 1, CRC patients and assessed associations between F nucleatum presence and clinical characteristics, CRC-specific mortality, and somatic mutations. F nucleatum , which was present in This association was restricted to non-hypermutated, microsatellite-stable tumors HR, 2. Only F nucleatum subspecies animalis , the main subspecies detected Additional adjustment for tumor stage suggests that the effect of F nucleatum on mortality is partly driven by a stage shift.
F nucleatum , and particularly subspecies animalis , was associated with a higher CRC-specific mortality and specific somatic mutated genes.
Our findings identify the F nucleatum subspecies animalis as negatively impacting CRC mortality which may occur through a stage shift and its effect on chemoresistance. The rapid advances in DNA sequencing technologies have allowed unbiased and comprehensive identification of pathogens in human tissues 1 , 2. Microbes are not only expected to play a role in susceptibility to some cancers but also in therapeutic response 5. A well-characterized example is gastric cancers, of which , of all new cancer cases, worldwide, were attributable to Helicobacter pylori infections in 4 , 6.
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In a subset of colorectal cancer CRC cases, Fusobacterium nucleatum , an inhabitant of the oral cavity and gastrointestinal tract, has been found to be enriched in tumor tissues 7 - Multiple mechanisms have been described by which the F nucleatum may promote CRC. The presence of F nucleatum in colorectal CR tumors is known to be associated with poor prognosis and resistance to chemotherapy However, less is known about tumor and patient attributes in relation to F nucleatum in CRC.
